Bone and Joint Institute

Title

Antibacterial Activity of Polymers: Discussions on the Nature of Amphiphilic Balance

Document Type

Article

Publication Date

3-18-2019

Journal

Angewandte Chemie - International Edition

Volume

58

Issue

12

First Page

3690

Last Page

3693

URL with Digital Object Identifier

10.1002/anie.201813810

Abstract

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The purpose of this Viewpoint is to discuss the molecular design principles that guide development of synthetic antimicrobial polymers, especially those intended to mimic the structure of host defense peptides (HDPs). In particular, we focus on the principle of “amphiphilic balance” as it relates to some recently developed polyphosphoniums with somewhat atypical structure. We find that the fundamental concept of amphiphilic balance is still applicable to these new polymers, but that the method to achieve such balance is somewhat unique. We then briefly outline the future challenges and opportunities in this field.

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