Bone and Joint Institute

Document Type


Publication Date



Angewandte Chemie - International Edition





First Page


Last Page


URL with Digital Object Identifier



© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The purpose of this Viewpoint is to discuss the molecular design principles that guide development of synthetic antimicrobial polymers, especially those intended to mimic the structure of host defense peptides (HDPs). In particular, we focus on the principle of “amphiphilic balance” as it relates to some recently developed polyphosphoniums with somewhat atypical structure. We find that the fundamental concept of amphiphilic balance is still applicable to these new polymers, but that the method to achieve such balance is somewhat unique. We then briefly outline the future challenges and opportunities in this field.


This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copy editing, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record

The version of record can be found at:

Palermo, E. F., Lienkamp, K., GIllies, E. R., & Ragogna, P. J. (2019). Antibacterial Activity of Polymers: Discussions on the Nature of Amphiphilic Balance. Angewandte Chemie International Edition, 58 (12), p. 3690-3693. DOI:

Find in your library

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.