Bone and Joint Institute
Document Type
Article
Publication Date
3-18-2019
Journal
Angewandte Chemie - International Edition
Volume
58
Issue
12
First Page
3690
Last Page
3693
URL with Digital Object Identifier
10.1002/anie.201813810
Abstract
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The purpose of this Viewpoint is to discuss the molecular design principles that guide development of synthetic antimicrobial polymers, especially those intended to mimic the structure of host defense peptides (HDPs). In particular, we focus on the principle of “amphiphilic balance” as it relates to some recently developed polyphosphoniums with somewhat atypical structure. We find that the fundamental concept of amphiphilic balance is still applicable to these new polymers, but that the method to achieve such balance is somewhat unique. We then briefly outline the future challenges and opportunities in this field.
Notes
This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copy editing, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record
The version of record can be found at:
Palermo, E. F., Lienkamp, K., GIllies, E. R., & Ragogna, P. J. (2019). Antibacterial Activity of Polymers: Discussions on the Nature of Amphiphilic Balance. Angewandte Chemie International Edition, 58 (12), p. 3690-3693. DOI: https://doi.org/10.1002/anie.201813810