Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner

Authors

Justin J. Tse, Robarts Research Institute
Joy Dunmore-Buyze, Robarts Research Institute
Maria Drangova, Robarts Research Institute
David W. Holdsworth, Robarts Research Institute

Document Type

Article

Publication Date

7-1-2018

Journal

Journal of Medical Imaging

Volume

5

Issue

3

URL with Digital Object Identifier

10.1117/1.JMI.5.3.033503

Abstract

© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Dual-energy microcomputed tomography (DECT) can provide quantitative information about specific materials of interest, facilitating automated segmentation, and visualization of complex three-dimensional tissues. It is possible to implement DECT on currently available preclinical gantry-based cone-beam micro-CT scanners; however, optimal decomposition image quality requires customized spectral shaping (through added filtration), optimized acquisition protocols, and elimination of misregistration artifacts. We present a method for the fabrication of customized x-ray filters - in both shape and elemental composition - needed for spectral shaping. Fiducial markers, integrated within the sample holder, were used to ensure accurate co-registration between sequential low- and high-energy image volumes. The entire acquisition process was automated through the use of a motorized filter-exchange mechanism. We describe the design, implementation, and evaluation of a DECT system on a gantry-based-preclinical cone-beam micro-CT scanner.

Notes

© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

This article was originally published at:

Justin J. Tse, Joy Dunmore-Buyze, Maria Drangova, and David W. Holdsworth "Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner," Journal of Medical Imaging 5(3), 033503 (21 August 2018). https://doi.org/10.1117/1.JMI.5.3.033503

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.