Bone and Joint Institute
Document Type
Article
Publication Date
8-1-2020
Journal
Applied Sciences (Switzerland)
Volume
10
Issue
16
URL with Digital Object Identifier
10.3390/app10165642
Abstract
© 2020 by the authors. Scaffolds are thought to be a key element needed for successful cartilage repair treatments, and this prospective extension study aimed to evaluate long-term structural and clinical outcomes following osteochondral defect treatment with a cell-free biphasic scaffold. Structural outcomes were assessed using quantitative 3-D magnetic resonance imaging (MRI) and morphological segmentation to determine the percentage of defect filling and repair cartilage T2 relaxation times, and clinical outcomes were determined with the modified Cincinnati Rating System, and the Knee Injury and Osteoarthritis Outcome Score (KOOS). Seventeen subjects with osteochondral defects in the knee were treated with ChondroMimetic scaffolds, from which 15 returned for long-term evaluation at a mean follow-up of 7.9 - 0.3 years. The defects treated were trochlear donor sites for mosaicplasty in 13 subjects, and medial femoral condyle defects in 2 subjects. MRI analysis of scaffold-treated defects found a mean total defect filling of 95.2 - 3.6%, and a tissue mean T2 relaxation time of 52.5 - 4.8 ms, which was identical to the T2 of ipsilateral control cartilage (52.3 - 9.2 ms). The overall modified Cincinnati Rating System score was statistically significant from baseline (p = 0.0065), and KOOS subscales were equivalent to other cartilage repair techniques. ChondroMimetic treatment resulted in a consistently high degree of osteochondral defect filling with durable, cartilage-like repair tissue at 7.9 years, potentially associated with clinical improvement.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Notes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
The article was originally published as:
Berta, A.; Shive, M.S.; Lynn, A.K.; Getgood, A.; Totterman, S.; Busby, G.; Hollenstein, J.; Vásárhelyi, G.; Kéki, I.; Hangody, L. Follow-Up Study Evaluating the Long Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee. Appl. Sci. 2020, 10, 5642. https://doi.org/10.3390/app10165642