Bone and Joint Institute

Title

Human cerebral circuitry related to cardiac control: A neuroimaging meta-analysis

Document Type

Article

Publication Date

5-1-2016

Journal

Annals of Neurology

Volume

79

Issue

5

First Page

709

Last Page

716

URL with Digital Object Identifier

10.1002/ana.24642

Abstract

© 2016 American Neurological Association. Serious arrhythmias often follow stroke, highlighting the important role that the cerebral cortex has in neural regulation of the heart. Neuroimaging studies reveal patterns of activation associated with autonomic cardiovascular responses. Using the activation likelihood estimation, a meta-analysis was performed to identify cortical activation patterns related to heart rate and heart rate variability across studies that used differing stimuli of cardiovascular arousal. Consistent associations with heart rate and heart rate variability were observed in the anterior cingulate, amygdala, insula, and prefrontal cortex, among others. Also, evidence is provided of insular lateralization associated with autonomic cardiac responses. Ann Neurol 2016;79:709-716

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