Bone and Joint Institute
Human cerebral circuitry related to cardiac control: A neuroimaging meta-analysis
Document Type
Article
Publication Date
5-1-2016
Journal
Annals of Neurology
Volume
79
Issue
5
First Page
709
Last Page
716
URL with Digital Object Identifier
10.1002/ana.24642
Abstract
© 2016 American Neurological Association. Serious arrhythmias often follow stroke, highlighting the important role that the cerebral cortex has in neural regulation of the heart. Neuroimaging studies reveal patterns of activation associated with autonomic cardiovascular responses. Using the activation likelihood estimation, a meta-analysis was performed to identify cortical activation patterns related to heart rate and heart rate variability across studies that used differing stimuli of cardiovascular arousal. Consistent associations with heart rate and heart rate variability were observed in the anterior cingulate, amygdala, insula, and prefrontal cortex, among others. Also, evidence is provided of insular lateralization associated with autonomic cardiac responses. Ann Neurol 2016;79:709-716
