Bone and Joint Institute
Document Type
Article
Publication Date
1-1-2018
Journal
Bone and Joint Journal
Volume
100B
Issue
1
First Page
88
Last Page
94
URL with Digital Object Identifier
10.1302/0301-620X.100B1.BJJ-2017-0955.R1
Abstract
© 2018 Sprague et al. Aims The Fluid Lavage in Open Fracture Wounds (FLOW) trial was a multicentre, blinded, randomized controlled trial that used a 2 3 factorial design to evaluate the effect of irrigation solution (soap versus normal saline) and irrigation pressure (very low versus low versus high) on health-related quality of life (HRQL) in patients with open fractures. In this study, we used this dataset to ascertain whether these factors affect whether HRQL returns to pre-injury levels at 12-months post-injury. Patients and Methods Participants completed the Short Form-12 (SF-12) and the EuroQol-5 Dimensions (EQ-5D) at baseline (pre-injury recall), at two and six weeks, and at three, six, nine and 12-months postfracture. We calculated the Physical Component Score (PCS) and the Mental Component Score (MCS) of the SF-12 and the EQ-5D utility score, conducted an analysis using a multilevel generalized linear model, and compared differences between the baseline and 12- month scores. Results We found no clinically important differences between irrigating solutions or pressures for the SF-12 PCS, SF-12 MCS and EQ-5D. Irrespective of treatment, participants had not returned to their pre-injury function at 12-months for any of the three outcomes (p < 0.001). Conclusion Neither the composition of the irrigation solution nor irrigation pressure applied had an effect on HRQL. Irrespective of treatment, patients had not returned to their pre-injury HRQL at 12 months post-fracture.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Notes
This is an open-access article distributed under the terms of the Creative Commons Attributions license (CC-BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited.
The article was originally published at:
Sprague, S., Petrisor, B., Jeray, K., McKay, P., Heels-Ansdell, D., Schemitsch, E., Liew, S., Guyatt, G., Walter, S. D., & Bhandari, M. (2018). Wound irrigation does not affect health related quality of life after open fractures: Results of a randomized controlled trial. Bone Joint J 2018; 100-B:88–94. DOI: https://doi.org/10.1302/0301-620X.100B1.BJJ-2017-0955.R1