Osteoarthritis, cerebrovascular dysfunction and the common denominator of inflammation: a narrative review

Authors

B. K. Al-Khazraji
C. T. AppletonFollow
F. Beier
Kevin J Shoemaker
Birmingham

Document Type

Article

Publication Date

2018

Journal

OSTEOARTHRITIS AND CARTILAGE

Issue

4

URL with Digital Object Identifier

10.1016/j.joca.2018.01.011

Abstract

Objective

Population-based cohort studies suggest an association between osteoarthritis (OA) and cerebrovascular disease, yet the mechanisms underlying vascular comorbidities in OA remain unclear. The purpose of this narrative review is to discuss the literature examining inflammation in OA with a focus on physiological mechanisms, and whether overlapping mechanisms exist in cerebrovascular dysfunction.