The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

Authors

Sali M.K. Farhan, Schulich School of Medicine & Dentistry
Robert Bartha, Robarts Research Institute
Sandra E. Black, University of Toronto
Dale Corbett, University of Ottawa
Elizabeth Finger, Schulich School of Medicine & Dentistry
Morris Freedman, University of Toronto
Barry Greenberg, University of Toronto
David A. Grimes, L'Hôpital d'Ottawa
Robert A. Hegele, Robarts Research Institute
Chris Hudson, University of Waterloo
Peter W. Kleinstiver, Schulich School of Medicine & Dentistry
Anthony E. Lang, University of Toronto
Mario Masellis, University of Toronto
William E. McIlroy, University of Waterloo
Paula M. McLaughlin, Schulich School of Medicine & Dentistry
Manuel Montero-Odasso, Keenan Research Centre for Biomedical Science
David G. Munoz, Queen's University, Centre for Neuroscience Studies, Kingston
Douglas P. Munoz, University of Toronto
Stephen Strother, University of Toronto
Richard H. Swartz, Schulich School of Medicine & Dentistry
Sean Symons, University Health Network
Maria Carmela Tartaglia, University Health Network
Lorne Zinman, University of Toronto
Michael J. Strong, Robarts Research Institute

Document Type

Article

Publication Date

3-1-2017

Journal

Canadian Journal of Neurological Sciences

Volume

44

Issue

2

First Page

196

Last Page

202

URL with Digital Object Identifier

10.1017/cjn.2016.415

Abstract

Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.