18F-DCFPyL PET/CT in Oncocytoma

Authors

Jeremy Li, HanYang University, College of Medicine
Richard Xu, HanYang University, College of Medicine
Chun K. Kim, HanYang University, College of Medicine
François Bénard, HanYang University, College of Medicine
Anil Kapoor, HanYang University, College of Medicine
Glenn Bauman, HanYang University, College of MedicineFollow
Katherine A. Zukotynski, HanYang University, College of Medicine

Document Type

Article

Publication Date

12-1-2018

Journal

Clinical Nuclear Medicine

Volume

43

Issue

12

First Page

921

Last Page

924

URL with Digital Object Identifier

10.1097/RLU.0000000000002301

Abstract

A 76-year-old man with biochemical failure after primary radiotherapy for prostate cancer had no malignant disease detected on Tc-MDP bone scan and diagnostic CT. Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein, is overexpressed in prostate cancer cells. The PSMA-Targeted F-DCFPyL PET/CT demonstrated lymph node disease and photopenic defects in the left kidney associated with a cyst and biopsy-proven oncocytoma. Prostate-specific membrane antigen is expressed in the neovasculature of several solid tumors. It has been reported that PSMA expression is seen in approximately 50% of oncocytoma versus 76% of clear cell renal carcinomas. Biopsy confirmation is needed regardless of F-DCFPyL avidity. 99m 18 18