18F-DCFPyL PET/CT in Oncocytoma
Document Type
Article
Publication Date
12-1-2018
Journal
Clinical Nuclear Medicine
Volume
43
Issue
12
First Page
921
Last Page
924
URL with Digital Object Identifier
10.1097/RLU.0000000000002301
Abstract
A 76-year-old man with biochemical failure after primary radiotherapy for prostate cancer had no malignant disease detected on Tc-MDP bone scan and diagnostic CT. Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein, is overexpressed in prostate cancer cells. The PSMA-Targeted F-DCFPyL PET/CT demonstrated lymph node disease and photopenic defects in the left kidney associated with a cyst and biopsy-proven oncocytoma. Prostate-specific membrane antigen is expressed in the neovasculature of several solid tumors. It has been reported that PSMA expression is seen in approximately 50% of oncocytoma versus 76% of clear cell renal carcinomas. Biopsy confirmation is needed regardless of F-DCFPyL avidity. 99m 18 18