Quantification of joint inflammation in rheumatoid arthritis by time-resolved diffuse optical spectroscopy and tracer kinetic modeling

Document Type

Conference Proceeding

Publication Date

1-1-2015

Journal

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

URL with Digital Object Identifier

10.1117/12.2079811

Abstract

© 2015 SPIE. Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation, which can cause progressive joint damage and disability. Diffuse optical spectroscopy (DOS) and imaging have the potential to become potent monitoring tools for RA. We devised a method that combined time-resolved DOS and tracer kinetics modeling to rapidly and reliably quantify blood flow in the joint. Preliminary results obtained from two animals show that the technique can detect joint inflammation as early as 5 days after onset.

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