New and current clinical imaging techniques to study chronic obstructive pulmonary disease
Document Type
Article
Publication Date
7-16-2009
Journal
American Journal of Respiratory and Critical Care Medicine
Volume
180
Issue
7
First Page
588
Last Page
597
URL with Digital Object Identifier
https://doi.org/10.1164/rccm.200901-0159PP
Abstract
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by both small airway and parenchymal abnormalities. There is increasing evidence to suggest that these two morphologic phenotypes, although related, may have different clinical presentations, prognosis, and therapeutic responses to medications. With the advent of novel imaging modalities, it is now possible to evaluate these two morphologic phenotypes in large clinical studies using noninvasive or minimally invasive methods such as computed tomography (CT), magnetic resonance imaging (MRI), and optical coherence tomography (OCT). In this article, we provide an overview of these imaging modalities in the context of COPD and discuss their strengths as well as their limitations for providing quantitative COPD phenotypes.
Notes
This is an author-accepted manuscript of an article initially published by the American Thoracic Society. Final published version is available at: https://doi.org/10.1164/rccm.200901-0159PP