Anatomical distribution of 3He apparent diffusion coefficients in severe chronic obstructive pulmonary disease
Journal of Magnetic Resonance Imaging : JMRI
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PURPOSE: To evaluate the anatomical distribution of apparent diffusion coefficients (ADC) using hyperpolarized helium-3 (3He) MRI in chronic obstructive pulmonary disease (COPD).
MATERIALS AND METHODS: Hyperpolarized 3He MRI was performed in eight healthy and seven COPD subjects under breathhold conditions in the supine position to determine ADC values from diffusion-weighted images and evaluate anterior-posterior (AP) and superior-inferior (SI) differences.
RESULTS: ADC differences between anterior and posterior slices, DeltaAP, was 0.06 +/-0.01 cm2/second for healthy volunteers and 0.04 +/-0.02 cm2/second for COPD subjects and was significant for each subject (P < 0.01). The AP ADC gradient was -3.98 x 10(-3) +/-0.59 cm2/second/cm for healthy volunteers and -2.04 x 10(-3) +/-0.89 cm2/second/cm for COPD subjects. The difference in ADC between superior and inferior regions of interest (ROIs), DeltaSI, was 0.02 +/-0.02 cm2/second for healthy volunteers and 0.10 +/-0.09 cm2/second for COPD subjects, which was significant for each subject (P < 0.05). The SI ADC gradient was -0.63 x 10(-3) +/-2.23 cm2/second/cm for healthy volunteers and -6.61 x 10(-3) +/-6.68 cm2/second/cm for COPD subjects. DeltaAP, AP-gradient, and SI-gradient were significantly different between healthy volunteers and COPD subjects (P < 0.05).
CONCLUSION: In all subjects, ADC anatomical differences were significant and mean ADC was dependent on anatomic location and disease status.
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This is the peer reviewed version of the following article: A Evans, D McCormack, A Ouriadov, R Etemad-Rezai, G Santyr & G Parraga (2007). Anatomical distribution of 3He apparent diffusion coefficients in severe chronic obstructive pulmonary disease, 26(6): 1537-1547, which has been published in final form at https://doi.org/10.1002/jmri.21205. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.