"Anatomical distribution of 3He apparent diffusion coefficients in seve" by Andrea Evans, David McCormack et al.
 

Anatomical distribution of 3He apparent diffusion coefficients in severe chronic obstructive pulmonary disease

Document Type

Article

Publication Date

12-1-2007

Journal

Journal of Magnetic Resonance Imaging : JMRI

Volume

26

Issue

6

First Page

1537

Last Page

1547

URL with Digital Object Identifier

https://doi.org/10.1002/jmri.21205

Abstract

PURPOSE: To evaluate the anatomical distribution of apparent diffusion coefficients (ADC) using hyperpolarized helium-3 (3He) MRI in chronic obstructive pulmonary disease (COPD).

MATERIALS AND METHODS: Hyperpolarized 3He MRI was performed in eight healthy and seven COPD subjects under breathhold conditions in the supine position to determine ADC values from diffusion-weighted images and evaluate anterior-posterior (AP) and superior-inferior (SI) differences.

RESULTS: ADC differences between anterior and posterior slices, DeltaAP, was 0.06 +/-0.01 cm2/second for healthy volunteers and 0.04 +/-0.02 cm2/second for COPD subjects and was significant for each subject (P < 0.01). The AP ADC gradient was -3.98 x 10(-3) +/-0.59 cm2/second/cm for healthy volunteers and -2.04 x 10(-3) +/-0.89 cm2/second/cm for COPD subjects. The difference in ADC between superior and inferior regions of interest (ROIs), DeltaSI, was 0.02 +/-0.02 cm2/second for healthy volunteers and 0.10 +/-0.09 cm2/second for COPD subjects, which was significant for each subject (P < 0.05). The SI ADC gradient was -0.63 x 10(-3) +/-2.23 cm2/second/cm for healthy volunteers and -6.61 x 10(-3) +/-6.68 cm2/second/cm for COPD subjects. DeltaAP, AP-gradient, and SI-gradient were significantly different between healthy volunteers and COPD subjects (P < 0.05).

CONCLUSION: In all subjects, ADC anatomical differences were significant and mean ADC was dependent on anatomic location and disease status.

Notes

This is the peer reviewed version of the following article: A Evans, D McCormack, A Ouriadov, R Etemad-Rezai, G Santyr & G Parraga (2007). Anatomical distribution of 3He apparent diffusion coefficients in severe chronic obstructive pulmonary disease, 26(6): 1537-1547, which has been published in final form at https://doi.org/10.1002/jmri.21205. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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