Free-breathing Functional Pulmonary MRI: Response to Bronchodilator and Bronchoprovocation in Severe Asthma

Authors

Dante P I Capaldi
Khadija Sheikh
Rachel L Eddy
Fumin Guo
Sarah Svenningsen
Parameswaran Nair
David G McCormack
Grace Parraga

Document Type

Article

Publication Date

5-24-2017

Journal

Academic Radiology

Volume

24

Issue

10

First Page

1268

Last Page

1276

URL with Digital Object Identifier

https://doi.org/10.1016/j.acra.2017.04.012

Abstract

RATIONALE AND OBJECTIVES: Ventilation heterogeneity is a hallmark feature of asthma. Our objective was to evaluate ventilation heterogeneity in patients with severe asthma, both pre- and post-salbutamol, as well as post-methacholine (MCh) challenge using the lung clearance index, free-breathing pulmonary

MATERIALS AND METHODS: Sixteen severe asthmatics (49 ± 10 years) provided written informed consent to an ethics board-approved protocol. Spirometry, plethysmography, and multiple breath nitrogen washout to measure the lung clearance index were performed during a single visit within 15 minutes of MRI. Inhaled-gas MRI and FDMRI were performed pre- and post-bronchodilator to generate VDP. For asthmatics with forced expiratory volume in 1 second (FEV

RESULTS: Hyperpolarized

CONCLUSIONS: FDMRI VDP generated in free-breathing asthmatic patients was correlated with static inspiratory breath-hold

Notes

This is an author-accepted manuscript of an article initially published by Elsevier. Final published version is available at: https://doi.org/10.1016/j.acra.2017.04.012

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