Document Type
Article
Publication Date
4-12-2018
Journal
PLoS One
Volume
13
Issue
4
First Page
0191172
Last Page
0191172
URL with Digital Object Identifier
https://doi.org/10.1371/journal.pone.0204633
Abstract
AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk.
METHODS AND RESULTS: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C.
CONCLUSIONS: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Citation of this paper:
Lorenz MW, Gao L, Ziegelbauer K, Norata GD, Empana JP, et al. (2018) Correction: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. PLOS ONE 13(9): e0204633. https://doi.org/10.1371/journal.pone.0204633
Notes
This is the final published version of record of the following article: MW Lorenz, L. Gao, K. Ziegelbauer, GD Norata, JP Empana, I Schmidtmann... PROG-IMT study group. (2018). Predictive value for caridovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. PLoS One. 13(9): e0204633, which is openly accessible at https://doi.org/10.1371/journal.pone.0204633.