Dietary intervention to reverse carotid atherosclerosis
Document Type
Article
Publication Date
3-16-2010
Journal
Circulation
Volume
121
Issue
10
First Page
1200
Last Page
1208
URL with Digital Object Identifier
https://doi.org/10.1161/CIRCULATIONAHA.109.879254
Abstract
BACKGROUND: It is currently unknown whether dietary weight loss interventions can induce regression of carotid atherosclerosis.
METHODS AND RESULTS: In a 2-year Dietary Intervention Randomized Controlled Trial-Carotid (DIRECT-Carotid) study, participants were randomized to low-fat, Mediterranean, or low-carbohydrate diets and were followed for changes in carotid artery intima-media thickness, measured with standard B-mode ultrasound, and carotid vessel wall volume (VWV), measured with carotid 3D ultrasound. Of 140 complete images of participants (aged 51 years; body mass index, 30 kg/m(2); 88% men), higher baseline carotid VWV was associated with increased intima-media thickness, age, male sex, baseline weight, blood pressure, and insulin levels (P
CONCLUSIONS: Two-year weight loss diets can induce a significant regression of measurable carotid VWV. The effect is similar in low-fat, Mediterranean, or low-carbohydrate strategies and appears to be mediated mainly by the weight loss-induced decline in blood pressure. Clinical Trial Registration- http://www.clinicaltrials.gov. Unique Identifier: NCT00160108.
Notes
This is an author accepted manuscript of an article initially published by the American Heart Association in Circulation. The final published version is available at: https://doi.org/10.1161/CIRCULATIONAHA.109.879254