Anatomy and Cell Biology Publications
Document Type
Conference Proceeding
Publication Date
3-6-2018
Issue
1058017
Journal
Proceedings of SPIE
Volume
10580
URL with Digital Object Identifier
https://doi.org/10.1117/12.2292925
Abstract
Dilatation of the cerebral ventricles is a common condition in preterm neonates with intraventricular hemorrhage (IVH). Post Hemorrhagic Ventricular Dilatation (PHVD) can lead to lifelong neurological impairment caused by ischemic injury due to increased intracranial pressure, and without treatment can lead to death. Previously, we have developed and validated a 3D ultrasound (US) system to monitor the progression of ventricle volumes (VV) in IVH patients; however, many patients with severe PHVD have ventricles so large they cannot be imaged within a single 3D US image. This limits the utility of atlas based segmentation algorithms required to measure VV as parts of the ventricles are in separate 3D US images, and thus, an already challenging segmentation becomes increasingly difficult to solve. Without a more automated segmentation, the clinical utility of 3D US ventricle volumes cannot be fully realized due to the large number of images and patients required to validate the technique in a clinical trials. Here, we describe the initial results of an automated ‘stitching’ algorithm used to register and combine multiple 3D US images of the ventricles of patients with PHVD. Our registration results show that we were able to register these images with an average target registration error (TRE) of 4.25±1.95 mm.
Notes
Paper originally presented at SPIE's Medical Imaging 2018: Ultrasonic Imaging and Tomography event March 6, 2018 and openly available as part of the Conference Proceedings available at: https://doi.org/10.1117/12.2292925