"Membrane-lipid homeostasis in a prodromal rat model of Alzheimer's dis" by Sarah Caughlin, Shikhar Maheshwari et al.
 

Anatomy and Cell Biology Publications

Title

Membrane-lipid homeostasis in a prodromal rat model of Alzheimer's disease: Characteristic profiles in ganglioside distributions during aging detected using MALDI imaging mass spectrometry

Document Type

Article

Publication Date

6-2018

Issue

6

Journal

Biochimica et Biophysica Acta-General Subjects

Volume

1862

First Page

1327

Last Page

1338

URL with Digital Object Identifier

https://doi.org/10.1016/j.bbagen.2018.03.011

Abstract

Background: Accumulation of simple gangliosides GM2 and GM3, and gangliosides with longer long-chain bases (d20:1) have been linked to toxicity and the pathogenesis of Alzheimer's disease (AD). Conversely, complex gangliosides, such as GM1, have been shown to be neuroprotective. Recent evidence using matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS) has demonstrated that a-series gangliosides are differentially altered during normal aging, yet it remains unclear how simple species are shifting relative to complex gangliosides in the prodromal stages of AD. Methods: Ganglioside profiles in wild-type (Wt) and transgenic APP21 Fischer rats were detected and quantified using MALDI-IMS at PO (birth), 3, 12, and 20 months of age and each species quantified to allow for individual species comparisons. Results: Tg APP21 rats were found to have a decreased level of complex gangliosides in a number of brain regions as compared to Wt rats and showed higher levels of simple gangliosides. A unique pattern of expression was observed in the white matter as compared to gray matter regions, with an age-dependent decrease in GD1 d18:1 species observed and significantly elevated levels of GM3 in Tg APP21 rats. Conclusions: These results are indicative of a pathological shift in ganglioside homeostasis during aging that is exacerbated in Tg APP21 rats. General significance: Ganglioside dysregulation may occur in the prodromal stages of neurodegenerative diseases like AD.

This document is currently not available here.

Find in your library

Plum Print visual indicator of research metrics
PlumX Metrics
  • Citations
    • Citation Indexes: 35
  • Usage
    • Abstract Views: 5
  • Captures
    • Readers: 39
  • Mentions
    • News Mentions: 1
see details

Share

COinS