Anatomy and Cell Biology Publications
Title
Reductions in muscle quality and quantity in chronic inflammatory demyelinating polyneuropathy patients assessed by magnetic resonance imaging
Document Type
Article
Publication Date
9-2018
Issue
3
Journal
Muscle & Nerve
Volume
58
First Page
396
Last Page
401
URL with Digital Object Identifier
https://doi.org/10.1002/mus.26159
Abstract
Introduction: Weakness in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) may be caused by decreases in muscle quantity and quality, but this has not been explored. Methods: Twelve patients with CIDP (mean age 61 years) and 10 age-matched (mean age 59 years) control subjects were assessed for ankle dorsiflexion strength, and two different MRI scans (T1 and T2) of leg musculature. Results: Isometric strength was 36% lower in CIDP patients compared with controls. Tibialis anterior muscle volumes of CIDP patients were smaller by approximate to 17% compared with controls, and non-contractile tissue volume was approximate to 58% greater in CIDP patients. When normalized to total muscle or corrected contractile volume, strength was approximate to 29% and approximate to 18% lower, respectively, in CIDP patients. Discussion: These results provide insight into the structural integrity of muscle contractile proteins and pathologic changes to whole-muscle tissue composition that contribute to impaired muscle function in CIDP. Muscle Nerve58: 396-401, 2018
