Title

Milder Alzheimer's Disease Pathology in Heart Failure and Atrial Fibrillation

Authors

Luciano A. Sposato, Western UniversityFollow
Estefania Ruiz Vargas, Western University
Patricia M. Riccio, Vascular Research Institute
Jon B. Toledo, University of Pennsylvania
John Q. Trojanowski, University of Pennsylvania
Walter A. Kukull, National Alzheimer’s Coordinating Center
Lauren E. Cipriano, Western UniversityFollow
Antonia Nucera, Western University
Shawn N. Whitehead, Western University; National Research Council of CanadaFollow
Vladimir Hachinski, Western University

Document Type

Article

Publication Date

7-2017

Issue

7

Journal

Alzheimer’s and Dementia

Volume

13

First Page

770

Last Page

777

URL with Digital Object Identifier

https://doi.org/10.1016/j.jalz.2016.12.002

Abstract

Introduction:Heart failure (HF) and atrial fibrillation (AF) have been associated with a higher risk of Alzheimer’s disease (AD). Whether HF and AF are related to AD by enhancing AD neuropathological changes is unknown.

Methods:We applied network analyses and multiple logistic regression models to assess the association between HF and AF with severity of AD neuropathology in patients from the National Alzheimer’s Coordinating Center database with primary neuropathological diagnosis of AD.

Results:We included 1593 patients, of whom 129 had HF and 250 had AF. HF and AF patients were older and had milder AD pathology. In the network analyses, HF and AF were associated with milder AD neuropathology. In the regression analyses, age (odds ratio [OR] 0.94, 95%

Notes

Published in final edited form as: Alzheimers Dementia. 2017 July ; 13(7): 770–777. doi:10.1016/j.jalz.2016.12.002