Physiology and Pharmacology Publications

Title

Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-β receptor signaling pathways contributes to renal fibrosis

Document Type

Article

Publication Date

12-27-2013

Journal

Journal of Biological Chemistry

Volume

288

Issue

52

First Page

37319

Last Page

37331

URL with Digital Object Identifier

10.1074/jbc.M113.492793

Abstract

Background: The role for proteinase-activated receptor (PAR)-2 in the pathogenesis of renal fibrosis is not previously described. Results: PAR2 -/- mice displayed attenuated renal fibrosis in vivo. PAR2 transactivation of EGF and TGFβ receptor signaling pathways induced Smad2 phosphorylation and connective tissue growth factor gene expression. Conclusion: PAR2 activation results in profibrotic signaling and gene expression. Significance: PAR2 represents a potential therapeutic target for chronic kidney disease. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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