Microbiology & Immunology Publications
Title
Local and diffuse bacterial adherence on uroepithelial cells
Document Type
Article
Publication Date
12-1-2001
Journal
FEMS Immunology and Medical Microbiology
Volume
32
Issue
1
First Page
37
Last Page
41
URL with Digital Object Identifier
10.1016/S0928-8244(01)00269-3
Abstract
Forty-two healthy women were randomized to receive one of three encapsulated Lactobacillus rhamnosus GR-1 plus Lactobacillus fermentum RC-14 probiotic dosage regimens or L. rhamnosus GG by mouth each day for 28 days. However, the vaginal flora, assessed by Nugent scoring, was only normal in 40% of the cases, and 14 patients had asymptomatic bacterial vaginosis. Treatment with L. rhamnosus GR-1/L. fermentum RC-14 once and twice daily correlated with a healthy vaginal flora in up to 90% of patients, and 7/11 patients with bacterial vaginosis converted to normal or intermediate scores within 1 month. Ingestion of L. rhamnosus GG failed to have an effect. This study confirms the potential efficacy of orally administered lactobacilli as a non-chemotherapeutic means to restore and maintain a normal urogenital flora, and shows that over 10 viable organisms per day is the required dose. © 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved. 8