Microbiology & Immunology Publications

Bacterial biofilms on devices used in nephrology

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Gut Microbes






Introduction: Studies with a follow-up of <8 weeks have indicated immune-preserving efects of yogurt probiotic supplementation among HIV patients. To evaluate the impact of 25 weeks use of probiotics, a randomized, double blind, controlled study was undertaken on 65 women who were naïve to anti-retroviral treatment. Results: Ten participants were excluded post-randomization due to non-eligibility. Thirty participants were assigned placebo, of whom 25 completed the study versus 19 of 25 completing the study in the probiotics group (p = 0.5). From baseline to 10 weeks follow-up, the CD4 count declined on average 3 CD4 cells/μl (95% Confdence Interval: -97; 91) with placebo versus an increase of 50 cells/μl (95% CI: -61; 162) with probiotics (p = 0.5). From baseline to 25 weeks, the CD4 count increased with 19 cells/μl (95% CI: -90; 129) in the placebo group versus 46 cells/μl (95% CI: -100; 192) with probiotics (p = 0.8). No diferences in immune markers, diarrhea incidence or adverse events were observed. Discussion: Lactobacillus GR-1 a nd RC-14 may be safely consumed at 2×10 CFU/day by moderately immune compromised HIV patients but this did not universally preserve immune-function. Patients and Methods: Women were randomized to receive oral capsules containing Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 (2×10 colony forming units) or placebo twice daily for 25 weeks. The CD4 count and immune markers (IgG, IgE, IFNγ and IL-10) were measured at baseline and during follow-up, the occurrence of diarrhea was reported daily. © 2011 Landes Bioscience. 9 9

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