Electronic Thesis and Dissertation Repository


Master of Science




Chronik, Blaine A.


Delta relaxation enhanced magnetic resonance (dreMR) is a magnetic resonance imaging (MRI) method that produces contrast based on longitudinal relaxation dispersion. Through modulation of the magnetic field using an actively-shielded, field-cycling insert coil, this technique increases probe specificity and suppresses remaining signal. However, significant improvements are needed. This thesis addresses two advancements in dreMR with a focus on optimizing design procedures. A general procedure was developed to design split power solenoid magnets. The procedure was then applied to the design of a switched-field exposure system. A coil was constructed and the method was validated. This procedure can be used for to optimize dreMR coil primary windings. Next, a simulation tool was developed to model tissue magnetization as a function of time and magnetic field. Polarization sequences were discovered that maximize dispersion-based contrast. These optimized design procedures may add to future developments in dreMR technology.