Master of Science
Chronik, Blaine A.
Delta relaxation enhanced magnetic resonance (dreMR) is a magnetic resonance imaging (MRI) method that produces contrast based on longitudinal relaxation dispersion. Through modulation of the magnetic field using an actively-shielded, field-cycling insert coil, this technique increases probe specificity and suppresses remaining signal. However, significant improvements are needed. This thesis addresses two advancements in dreMR with a focus on optimizing design procedures. A general procedure was developed to design split power solenoid magnets. The procedure was then applied to the design of a switched-field exposure system. A coil was constructed and the method was validated. This procedure can be used for to optimize dreMR coil primary windings. Next, a simulation tool was developed to model tissue magnetization as a function of time and magnetic field. Polarization sequences were discovered that maximize dispersion-based contrast. These optimized design procedures may add to future developments in dreMR technology.
Martire, Daniel J., "Optimization of Design Procedures for Delta Relaxation Enhanced Magnetic Resonance" (2018). Electronic Thesis and Dissertation Repository. 5257.