Electronic Thesis and Dissertation Repository


Master of Science


Epidemiology and Biostatistics


William Hodge

2nd Supervisor

Neil Klar

Joint Supervisor


Our objectives were to compare the efficacy and safety between selective laser trabeculoplasty (SLT) and argon laser trabeculoplasty (ALT) for the open-angle glaucoma patients who had 360-degree SLT previously and to explore the baseline predictors for the treatment success. Data were obtained from a multicenter, patient-masked, randomised, parallel-group, active-controlled trial. The enrolled patients were randomly assigned to receive either SLT or ALT. At 12-month follow-up, the mean intraocular pressure (IOP) reduction was 3.35 mmHg and 3.36 mmHg after SLT and ALT respectively. The difference of mean IOP reduction was -0.01 mmHg (n=115). The 95% CI of the difference was between -1.86 to 1.84 mmHg and was within the predetermined equivalence margin (-3 to +3 mmHg). Baseline IOP and number of glaucoma medication were significant predictors of treatment success (OR, 1.19 and 0.63). The findings suggest that although SLT had an equivalent IOP-lowering effect as ALT after the failure of 360-degree SLT, repeat laser treatments had a lower efficacy than the primary ones.

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