Electronic Thesis and Dissertation Repository


Master of Science




Robert Petrella


Studies have found a link between cardiovascular risk factors (CVRFs) and Alzheimer’s disease however; the mechanism by which CVRFs increase the risk of cognitive decline is not fully understood. The current study attempts to improve CVRFs in order to enhance cognition in older adults. Primary outcomes include ambulatory and clinical resting systolic and diastolic blood pressure (SBP; DBP). In total, 89 community-dwelling older adults with subjective cognitive complaints were randomized to either a multiple-modality mind-motor (M4) exercise or a multiple-modality (M2) exercise only. Significance was found in nighttime peak SBP (6.55 mmHg, p=.04) between groups, with a decrease in M2 compared to M4. Clinical resting SBP also decreased (6.99 mmHg, p=.03) between groups, whereby M4 further decreased compared to M2. Both M2 and M4 have some influence on ambulatory and clinical resting BP however, further research is required to elicit the effects of M4 and M2 on CVRFs.

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