Electronic Thesis and Dissertation Repository


Master of Science


Medical Biophysics


Dr. Mair Zamir

2nd Supervisor

Dr. Tamie Poepping

Joint Supervisor


Stroke remains one of the leading causes of death in North America. Approximately half of all ischemic episodes are a direct result of carotid artery disease, which can be categorized into either obstructive or sclerotic disease. Obstructive disease is a result of plaque development that imposes a direct limitation on the physical space available for blood flow. Sclerotic disease involves the hardening of the arteries as is often a result of aging and disease. While the impact of vessel stiffening is not as obvious, it does interfere with wave propagation. Effects of obstructive and sclerotic disease were studied using a lumped parameter model that was designed to match an experimental in vitro flow loop. Mild to moderate stenosis had minimal impact on blood supply to the brain. Both stiffness of the carotid artery and severe stenosis ( 70%) had a significant reduction on blood supply to the brain (p<0.01).