Overall survival and biochemical failure-free survival comparison of brachytherapy treatment options versus external beam radiation therapy for both low and intermediate-risk prostate cancer: A propensity-score matched analysis
Master of Science
Epidemiology and Biostatistics
Dr. George Rodrigues
Purpose: This study compares overall survival (OS) and biochemical failure-free survival (bFFS) in low- and intermediate-risk prostate cancer patients that received brachytherapy [low-dose-rate brachytherapy (LDR-BT) or high-dose-rate brachytherapy with external beam radiation therapy (HDR-BT+EBRT)] versus external beam radiation therapy (EBRT) alone.
Materials/Methods: Patient data was obtained from the ProCaRS database, which contains 7974 prostate cancer patients treated at four Canadian institutions. Propensity score (PS) matching was used to generate matched cohorts with balanced baseline prognostic factors.
Results/Conclusions: Final PS matches included two 1:1 intermediate-risk patient matches, LDR-BT vs. EBRT (total n = 254) and HDR-BT+EBRT vs. EBRT (total n=388), and a 4:1 (LDR-BT:EBRT) low-risk match (total n=400). Hazard ratios for OS were 0.79 (p=0.69), 0.64 (p=0.47), and 1.41 (p=0.50), respectively. Hazard ratios for bFFS were 0.22 (p=0.001), 0.48 (p=0.007), and 0.35 (p=0.004), respectively.
Conclusions: PS matching showed BT significantly improved bFFS but not OS in matched prostate cancer patients.
Smith, Graham D., "Overall survival and biochemical failure-free survival comparison of brachytherapy treatment options versus external beam radiation therapy for both low and intermediate-risk prostate cancer: A propensity-score matched analysis" (2014). Electronic Thesis and Dissertation Repository. 2212.