Electronic Thesis and Dissertation Repository


Master of Science


Epidemiology and Biostatistics


Dr. Amit X. Garg


A kidney stone in a person with one kidney requires urgent attention which may result in surgical and/or hospital attention. We conducted a matched retrospective cohort study to determine if living kidney donors compared to healthy non-donors have a higher risk of: 1) kidney stones with surgical intervention, and 2) hospital encounters for kidney stones. We reviewed and linked information from pre-donation charts to Ontario healthcare databases. We selected healthy non-donors from the general population, matching ten non-donors to every donor, to generate a cohort of 2,019 donors and 20,190 non-donors. There was no difference in the rate of 1) kidney stones with surgical intervention comparing donors to non-donors (8.3 vs 9.7 events/10,000 person-years; rate ratio[RR] 0.85; 95% confidence interval[CI] 0.47-1.53), and 2) hospital encounters for kidney stones (12.1 vs 16.1 events/10,000 person-years; RR 0.75; 95% CI 0.45-1.24). These interim results are reassuring for the safety of living kidney donation.