Date of Award


Degree Type


Degree Name

Master of Science




Dr. Elizabeth Gillies


Rigid poly(phenylene ethynylene) (PPE) polymers and dendrimers are composed of alternating phenyl rings and alkynebonds. Despite their inherent rigidity they have not yet been used as scaffolds for Gd(III) MRI contrast agents. This thesis examines the attachment of Gd(III) contrast agents to water-soluble PPE polymers in order to increase the contrast agent’s relaxivity. Two PPE polymers having Gd(III) chelates were synthesized but one showed poor water solubility and was not tested for its effects on relaxivity. The other’s relaxivity was tested, but was found to be lower than anticipated.

This was attributed to the assembly of the polymer into micrometer sized particles that inhibited the contrast agent’s relaxivity. Steps toward a Gd(III) contrast agent attached to the periphery of a PPE dendrimer are also reported in this work.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.