Jinlong Zhang

Date of Award


Degree Type


Degree Name

Master of Engineering Science


Mechanical and Materials Engineering


As the development of microfabrication technology, Micro Electro-Mechanical System (MEMS) devices have been extensively explored for practical biological and chemical applications. One fast growing research area of MEMS is the development of portable, all-in-one, point-of-care Lab-On-a-Chip devices. Lab-On-CD device is one of the most important branches of Lab-On-a-Chip technology through implementing experiments on a rotating disk. In this thesis, a microfluidics-based Lab-On-CD device has been developed where the whole process of blood separation and blood tests can be performed automatically and sequentially in one experiment. This Lab-On-CD device was fabricated using microfabrication techniques. The centrifugal force is adopted as the pumping mechanism when this device is placed on a rotating platform. It has been demonstrated that this device can achieve 99% blood separation efficiency for 12% hematocrit blood samples. As an example of this device suitable for blood tests, measurement of whole protein concentration of human blood sample has been carried out. Many other blood tests can also be performed on this simple Lab-On-CD device.



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