Date of Award


Degree Type


Degree Name

Master of Science




Dr. David Hill

Second Advisor

Dr. Edith Arany


In order to investigate the role of statins in beta (β)-cell regeneration, we used a model of streptozotocin (STZ)-induced β-cell injury, and attempted to affect neovascularization using atorvastatin (AT), in order to aid in β-cell recovery. The recruitment of EPCs, which readily home to sites of injury, would contribute to new blood vessel formation and deliver appropriate signals for β-cell regeneration. We hypothesized that the rate and capacity of the β-cell growth and regenerative processes would increase with AT. β-cell mass was expanded by postnatal day (PD) 44 and we observed a better glucose tolerance in STZ animals treated with 20 mg/kg AT. This treatment appeared to affect the neogenesis of islets and caused an increase in the number of endothelial cells (ECs). Our findings suggest a novel effect of statins and will help further elucidate the mechanisms of β-cell regeneration.



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