Date of Award
Master of Science
Dr. David Hill
Dr. Edith Arany
In order to investigate the role of statins in beta (β)-cell regeneration, we used a model of streptozotocin (STZ)-induced β-cell injury, and attempted to affect neovascularization using atorvastatin (AT), in order to aid in β-cell recovery. The recruitment of EPCs, which readily home to sites of injury, would contribute to new blood vessel formation and deliver appropriate signals for β-cell regeneration. We hypothesized that the rate and capacity of the β-cell growth and regenerative processes would increase with AT. β-cell mass was expanded by postnatal day (PD) 44 and we observed a better glucose tolerance in STZ animals treated with 20 mg/kg AT. This treatment appeared to affect the neogenesis of islets and caused an increase in the number of endothelial cells (ECs). Our findings suggest a novel effect of statins and will help further elucidate the mechanisms of β-cell regeneration.
Weese, Kelly C., "EFFECTS OF ATORVASTATIN ON THE REGENERATION OF PANCREATIC BETA CELLS AFTER STREPTOZOTOCIN TREATMENT IN THE NEONATAL RODENT" (2008). Digitized Theses. 4310.