Date of Award


Degree Type


Degree Name

Master of Science


Medical Biophysics


Dr. Brian K. Rutt

Second Advisor

Dr. Paula Foster

Third Advisor

Dr. Elizabeth Gillies


Gadolinium relaxation theory was investigated to correlate chemical structure with relaxivity. Relaxation theory was used to produce theoretical Nuclear Magnetic Resonance Dipersion profiles for Vasovist bound to Human Serum Albumin and compared to experimental results. Relaxation theory was used to calculate structural parameters for novel gadolinium MPO contrast agents. Magnetic relaxation switch agents are nanoparticles capable of sensing molecular interactions. These nanoparticles switch between a dispersed and clustered state depending on the presence of target analytes. Relaxation ratios were derived to predict changes in relaxation times upon nanoparticle clustering and compared to experimental results. Relaxation theory provides insights into the mechanics of and aides in the development of novel and more effective contrast agents.



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