Date of Award


Degree Type


Degree Name

Master of Science


Physiology and Pharmacology


Dr. Bryan Richardson

Second Advisor

Dr. Donglin Bai

Third Advisor

Dr. Arthur Brown


The low voltage (LV)/rapid eye movement (REM) behavioural state the high voltage(HV)/non-rapid eye movement (NREM) behavioural state are each suggested to have a unique functional role in fetal neurodevelopment, therefore requiring the existence of both behavioural states in appropriate proportions for optimal maturation. The present study examined the behavioural state cycling pattern in the ovine fetus near term and characterized the related changes in cerebral blood flow velocity (CBFV), utilizing a 20-MHz piezoelectric Doppler crystal transducer. Our results demonstrated the HV/NREM epoch duration to be positively correlated with that of the prior LV/REM epoch, as well as with that of the subsequent LV/REM epoch, suggesting a possible homeostatic behavioural state control mechanism in the fetus. Changes in CBFV were consistent with those previously demonstrated, suggesting the piezoelectric Doppler crystal transducer may be used to continuously measure CBFV under resting conditions and provide a relative measure of cerebral blood flow changes.



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