Date of Award
Master of Science
Dr. Qingping Feng
Sepsis is a complex clinical syndrome that results from a harmful or damaging
host response to infection. Sepsis is characterized by the production of proinflammatory
cytokines like TNF-a and IL-ip, which have been shown to contribute to cardiovascular
dysfunction. Annexin A5 is a phospholipid binding protein that has been shown to have
anti-inflammatory, anti-apoptotic and anti-coagulant properties. However, its effect on
cardiac function during sepsis has not been established. This thesis investigated the
effect of annexin A5 on myocardial cytokine production and cardiac function during
endotoxemia in mice. It was found that annexin A5 treatment at the onset of
endotoxemia abrogated TNF-a and IL-1P production and prevented cardiac dysfunction.
Annexin A5 likely interacts with cell-surface receptor TLR4 to inhibit myocardial
cytokine expression to protect against cardiac dysfunction during endotoxemia. These
results suggest that annexin A5 provides a novel protective role in the heart during
Arnold, Paul, "Annexin A5 Inhibits Myocardial Inflammation and Improves Cardiac Function during Endotoxemia in Mice" (2010). Digitized Theses. 3717.