Li Yue

Date of Award


Degree Type


Degree Name

Master of Science


Epidemiology and Biostatistics


Dr. Guangyong Zou

Second Advisor

Dr. Yun-Hee Choi


The performance of a medical diagnostic test yielding quantitative or ordinal measure­ ments is often assessed in terms of its AUC, area under the receiver operating characteristic curve. As new tests constantly being developed, an essential task is to compare multiple AUCs, commonly derived from the same group of subjects. For this purpose, previous research usually uses an omnibus chi-square test that is non-informative and lacks power. In this study, wc propose new methods of constructing simultaneous confidence intervals based on theory of nonparametric [/-statistics. To improve the small sample properties, we adapt the method of variance estimates recovery by obtaining confidence limits for each AUC based on logit and inverse sinh transformation. A large simulation study demon­ strates the good performance of our new method.



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