Date of Award
Master of Engineering Science
Dr. Timothy A. Newson
Aging-associated vision loss is increasingly prevalent in our population and intravitreal injections are commonly used to administer ocular drugs to the posterior segment of the eye. This work aims to visualize and predict the delivery of ocular drugs by combining micro- computed tomography (micro-CT) imaging and computational fluid dynamics (CFD) modeling. Intravitreal injections were administered into ex vivo porcine eyes and imaged for an extended period of time to track the progression of the injected drug mimic. Non-invasive imaging allowed for precise determination of contrast agent concentration, flow patterns and fate. A computational model was developed that provided quantitative agreement with the concentration values found in the experimental study and allowed for easy manipulation of parameters. The ability to accurately model drug transport following an intravitreal injection provides vital information to better understand the specific concentration and time frame for the drug to reach the target site
Smith, Corey Albert, "Development of Imaging Paradigms for Drug Distribution and Fate in the Eye" (2011). Digitized Theses. 3342.