Chemistry Publications

Document Type

Article

Publication Date

5-20-2021

Journal

Contact Dermatitis

URL with Digital Object Identifier

https://doi.org/10.1111/cod.13904

Abstract

Background: Allergic contact dermatitis to metals is diagnosed by applying a metal salt in a patch test. The bioavailability of the metal salt might depend on the choice of metal salt, the concentration, sweat composition, and pH.

Objectives: The main purpose of this study was to apply chemical speciation modelling, which is based on experimentally derived input data and calculates the concentrations of chemical forms (species) in solutions, to reproduce and discuss clinical patch test results of aluminium and chromium.

Methods: Joint Expert Speciation System (JESS), Hydra/Medusa, and Visual Minteq were employed to study the bioavailable fraction and chemical form of clinically applied aluminium and chromium salts as a function of salt type, applied concentration, sweat composition, and pH.

Results: Investigated aluminium and chromium salts can have a very low bioavailability with a large dependency on sweat composition, pH, metal salt, and concentration. Both aluminium and chromium ions could shift the pH towards acidic or basic values based on their chemical form.

Conclusions: Reported seasonal and inter-patient variability in positive reactions to aluminium is likely related to sweat pH and composition. Potassium dichromate increases the pH and aluminium and trivalent chromium chloride strongly decrease the pH, possibly increasing skin diffusion.

Notes

"This is the pre-peer reviewed version of the following article:

Nikpour, S. and Hedberg, Y.S. (2021), Using chemical speciation modelling to discuss variations in patch test reactions to different aluminium and chromium salts. Contact Dermatitis. Accepted Author Manuscript. https://doi.org/10.1111/cod.13904, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1111/cod.13904

This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."

Citation of this paper:

Nikpour, S. and Hedberg, Y.S. (2021), Using chemical speciation modelling to discuss variations in patch test reactions to different aluminium and chromium salts. Contact Dermatitis. Accepted Author Manuscript. https://doi.org/10.1111/cod.13904

Available for download on Friday, May 20, 2022

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