Title

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

Authors

Karen Horsburgh, Edinburgh Medical School
Joanna M. Wardlaw, The University of Edinburgh
Tom van Agtmael, University of Glasgow
Stuart M. Allan, Faculty of Biology, Medicine and Health
Mike L.J. Ashford, University of Dundee
Philip M. Bath, University of Nottingham
Rosalind Brown, Edinburgh Medical School
Jason Berwick, The University of Sheffield
M. Zameel Cader, University of Oxford Medical Sciences Division
Roxana O. Carare, University of Southampton, Faculty of Medicine
John B. Davis, University of Oxford Medical Sciences Division
Jessica Duncombe, Edinburgh Medical School
Tracy D. Farr, University of Nottingham
Jill H. Fowler, Edinburgh Medical School
Jozien Goense, College of Medical, Veterinary & Life Sciences
Alessandra Granata, University of Cambridge
Catherine N. Hall, University of Sussex
Atticus H. Hainsworth, St George’s, University of London
Adam Harvey, University of Glasgow
Cheryl A. Hawkes, The Open University
Anne Joutel, Inserm
Rajesh N. Kalaria, University of Newcastle upon Tyne, Faculty of Medical Sciences
Patrick G. Kehoe, Bristol Medical School
Catherine B. Lawrence, Faculty of Biology, Medicine and Health
Andy Lockhart, GlaxoSmithKline plc.
Seth Love, University of Bristol
Malcolm R. Macleod, Edinburgh Medical School
I. Mhairi Macrae, College of Medical, Veterinary & Life Sciences
Hugh S. Markus, University of Cambridge
Chris McCabe, College of Medical, Veterinary & Life Sciences
Barry W. McColl, University of Edinburgh, Roslin Institute
Paul J. Meakin, University of Dundee

Document Type

Article

Publication Date

1-1-2018

Journal

Clinical Science

Volume

132

Issue

8

First Page

851

Last Page

868

URL with Digital Object Identifier

10.1042/CS20171620

Abstract

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

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