Title

Measuring motivation and reward-related decision making in the rodent operant touchscreen system

Document Type

Article

Publication Date

1-1-2016

Journal

Current Protocols in Neuroscience

Volume

2016

First Page

8.34.1

Last Page

8.34.20

URL with Digital Object Identifier

10.1002/0471142301.ns0834s74

Abstract

This unit is designed to facilitate implementation of the fixed and progressive ratio paradigms and the effort-related choice task in the rodent touchscreen apparatus to permit direct measurement of motivation and reward-related decision making in this equipment. These protocols have been optimized for use in the mouse and reliably yield stable performance levels that can be enhanced or suppressed by systemic pharmacological manipulation. Instructions are also provided for the adjustment of task parameters to permit use in mousemodels of neurodegenerative disease. These tasks expand the utility of the rodent touchscreen apparatus beyond the currently available battery of cognitive assessment paradigms.

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