Title

Functional boundaries in the human cerebellum revealed by a multi-domain task battery

Document Type

Article

Publication Date

8-1-2019

Journal

Nature Neuroscience

Volume

22

Issue

8

First Page

1371

Last Page

1378

URL with Digital Object Identifier

10.1038/s41593-019-0436-x

Abstract

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. There is compelling evidence that the human cerebellum is engaged in a wide array of motor and cognitive tasks. A fundamental question centers on whether the cerebellum is organized into distinct functional subregions. To address this question, we employed a rich task battery designed to tap into a broad range of cognitive processes. During four functional MRI sessions, participants performed a battery of 26 diverse tasks comprising 47 unique conditions. Using the data from this multi-domain task battery, we derived a comprehensive functional parcellation of the cerebellar cortex and evaluated it by predicting functional boundaries in a novel set of tasks. The new parcellation successfully identified distinct functional subregions, providing significant improvements over existing parcellations derived from task-free data. Lobular boundaries, commonly used to summarize functional data, did not coincide with functional subdivisions. The new parcellation provides a functional atlas to guide future neuroimaging studies.

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