Title

Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential

Document Type

Article

Publication Date

7-1-2019

Journal

Trends in Neurosciences

Volume

42

Issue

7

First Page

458

Last Page

470

URL with Digital Object Identifier

10.1016/j.tins.2019.04.003

Abstract

© 2019 Elsevier Ltd The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key components in the closure of critical periods of heightened neuroplasticity. In animal models, manipulating PNNs outside this critical window can enhance cognition, suggesting a potentially therapeutic approach for attenuating cognitive decline. However, the crucial role of PNNs in plasticity and protection means that such therapeutic modulation must strike a careful balance: manipulation of PNNs to promote plasticity may have unintended negative consequences resulting from excessive plasticity or from exposure of neurons to neurotoxins.

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