Title

Self-appraisal decisions evoke dissociated dorsal-ventral aMPFC networks

Document Type

Article

Publication Date

4-15-2006

Journal

NeuroImage

Volume

30

Issue

3

First Page

1050

Last Page

1058

URL with Digital Object Identifier

10.1016/j.neuroimage.2005.10.030

Abstract

The anterior medial prefrontal cortex (aMPFC) is consistently active during personally salient decisions, yet the differential contributory processes of this region along the dorsal-ventral axis are less understood. Using a self-appraisal decision-making task and functional magnetic resonance imaging, we demonstrated task-dependent connectivity of ventral aMPFC with amygdala, insula, and nucleus accumbens, and dorsal aMPFC connectivity with dorsolateral PFC and bilateral hippocampus. These aMPFC networks appear to subserve distinct contributory processes inherent to self-appraisal decisions, specifically a dorsally mediated cognitive and a ventrally mediated affective/self-relevance network. © 2005 Elsevier Inc. All rights reserved.

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