Title

BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats.

Document Type

Article

Publication Date

4-26-2017

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Volume

37

Issue

17

First Page

4540

Last Page

4551

URL with Digital Object Identifier

10.1523/JNEUROSCI.3699-16.2017

Abstract

Habituation is a basic form of implicit learning and represents a sensory filter that is disrupted in autism, schizophrenia, and several other mental disorders. Despite extensive research in the past decades on habituation of startle and other escape responses, the underlying neural mechanisms are still not fully understood. There is evidence from previous studies indicating that BK channels might play a critical role in habituation. We here used a wide array of approaches to test this hypothesis. We show that BK channel activation and subsequent phosphorylation of these channels are essential for synaptic depression presumably underlying startle habituation in rats, using patch-clamp recordings and voltage-sensitive dye imaging in slices. Furthermore, positive modulation of BK channels

Notes

Version of record available as:

Zaman T, De Oliveira C, Smoka M, Narla C, Poulter M, Schmid S (2017) BK channels are essential for synaptic plasticity underlying habituation. J. Neuroscience 37(17):4540-4551. DOI: 10.1523/JNEUROSCI.3699-16.2017

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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