Title

Alterations in frontostriatal pathways in children born very preterm.

Document Type

Article

Publication Date

10-1-2013

Journal

Developmental medicine and child neurology

Volume

55

Issue

10

First Page

952

Last Page

958

URL with Digital Object Identifier

10.1111/dmcn.12198

Abstract

AIM: Children born very preterm (

METHOD: Twenty school-aged children born very preterm (11 males, nine females; mean age 8y 6mo, standard error [SE] 1.68mo, range 7y 7mo-9y 6mo; gestational age range 24-30wks, mean gestational age 26.9wks, SE 0.4wk; birthweight 988 g, SE 46 g, range 570-1424 g) without evidence of neonatal brain injury, and 20 sex- and age-matched term-born children (mean age 8y 4.8mo, SE 1.92mo; range 7y 2mo-9y-10.8mo) underwent neurodevelopmental assessment and diffusion tensor imaging.

RESULTS: Fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity were calculated within all white matter pathways and within frontostriatal projections. Children born preterm had decreased fractional anisotropy in the territories of the left external capsule, superior longitudinal fasciculus, uncinate fasciculus, and inferior fronto-occipital fasciculus. Measures of intelligence were negatively correlated with frontostriatal fractional anisotropy only in males born preterm.

INTERPRETATION: Results indicate that very preterm-born children exhibit white matter disturbances that persist into middle childhood, with potential sex differences in the association between these white matter alterations and cognitive function.

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