Bone and Joint Institute
Document Type
Article
Publication Date
8-12-2020
Journal
Polymer
Volume
202
URL with Digital Object Identifier
10.1016/j.polymer.2020.122638
Abstract
© 2020 Elsevier Ltd Self-immolative polymers (SIPs) depolymerize to small molecules through a cascade of reactions following cleavage of the polymer backbone or a specific terminal or focal point moiety by a stimulus. They have been developed using the principles of self-immolative spacers and low ceiling temperature (Tc) polymers. Key developments over the past couple of decades have been the polymerization of spacers to enable long reaction cascades, and the introduction of stimuli-responsive end-caps which have allowed depolymerization to be triggered in a controlled manner in response to a wide array of stimuli. This review will focus on the architectural evolution of SIPs over the past two decades from oligomers to dendrimers, linear polymers, cyclic polymers, graft copolymers, networks, and hyperbranched systems. We will discuss how the architecture influences the triggering and propagation of the reaction cascade and highlight how different architectures can provide advantages and disadvantages in terms of their synthesis and properties.
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Notes
This is an author-accepted manuscript. The publisher's version can be found at https://doi.org/10.1016/j.polymer.2020.122638