Bone and Joint Institute

Title

Surprising Antibacterial Activity and Selectivity of Hydrophilic Polyphosphoniums Featuring Sugar and Hydroxy Substituents

Document Type

Article

Publication Date

9-24-2018

Journal

Angewandte Chemie - International Edition

Volume

57

Issue

39

First Page

12707

Last Page

12710

URL with Digital Object Identifier

10.1002/anie.201806412

Abstract

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim There is currently an urgent need for the development of new antibacterial agents to combat the spread of antibiotic-resistant bacteria. We explored the synthesis and antibacterial activities of novel, sugar-functionalized phosphonium polymers. While these compounds exhibited antibacterial activity, we unexpectedly found that the control polymer poly(tris(hydroxypropyl)vinylbenzylphosphonium chloride) showed very high activity against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus and very low haemolytic activity against red blood cells. These results challenge the conventional wisdom in the field that lipophilic alkyl substituents are required for high antibacterial activity and opens prospects for new classes of antibacterial polymers.

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