Bone and Joint Institute

Title

Multi-stimuli-responsive self-immolative polymer assemblies

Document Type

Article

Publication Date

8-15-2018

Journal

Journal of Polymer Science, Part A: Polymer Chemistry

Volume

56

Issue

16

First Page

1868

Last Page

1877

URL with Digital Object Identifier

10.1002/pola.29070

Abstract

© 2018 Wiley Periodicals, Inc. Self-immolative polymers (SIPs) undergo depolymerization in response to the cleavage of stimuli-responsive end-caps from their termini. Some classes of SIPs, including polycarbamates, have depolymerization rates that depend on environmental factors such as solvent and pH. In previous work, hydrophobic SIPs have been incorporated into amphiphilic block copolymers and used to prepare nanoassemblies. However, stimuli-responsive hydrophilic blocks have not previously been incorporated. In this work, we synthesized amphiphilic copolymers composed of a hydrophobic polycarbamate SIP block and a hydrophilic poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) block connected by a UV light-responsive linker end-cap. It was hypothesized that after assembly of the block copolymers into nanoparticles, chain collapse of the PDMAEMA above its lower critical solution temperature (LCST) might change the environment of the SIP block, thereby altering its depolymerization rate. Self-assembly of the block copolymers was performed, and the depolymerization of the resulting assemblies was studied by fluorescence spectroscopy, dynamic light scattering, and NMR spectroscopy. At 20 °C, the system exhibited a selective response to the UV light. At 65 °C, above the LCST of PDMAEMA, the systems underwent more rapid depolymerization, suggesting that the increase in rate arising from the higher temperature dominated over environmental effects arising from chain collapse. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1868–1877.

This document is currently not available here.

Share

COinS