Bone and Joint Institute

Title

Functional aqueous assemblies of linear-dendron hybrids

Document Type

Article

Publication Date

1-15-2015

Journal

Journal of Polymer Science, Part A: Polymer Chemistry

Volume

53

Issue

2

First Page

148

Last Page

172

URL with Digital Object Identifier

10.1002/pola.27316

Abstract

© 2014 Wiley Periodicals, Inc. Linear-dendron (LD) hybrids are macromolecules comprising a linear polymer or oligomer conjugated at one or both termini with branched macromolecules called dendrons. Since their introduction approximately 2 decades ago, tremendous progress has been made in their synthesis, the study of their self-assembly, and toward their application in a variety of fields. This highlight is focused on aqueous assemblies of LD hybrids where function is imparted by the dendron, linear component, or both. These functions include the encapsulation and release of drug molecules, enhancement of cell uptake and targeting of specific tissues, and the stabilization of enzymes for catalysis. In addition, many stimuli-responsive LD hybrids that undergo changes in response to light, enzymes, pH, temperature, redox potential, or even multiple stimuli have been developed. LD hybrids can also be used to form networks via cross-linking reactions. Described here are the structure-property relationships underlying the functions of these materials, along with their potential applications.

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